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Cialix leads to cardio protection especially in the heart-attack patient if you have a heart failure patient which is typical for many of our models dilated myopathies pressure overload and weeks on end then this is where you may be in the remission or the irreversible damage state so the question is is there a link between the physiology of pressure volume unloading and cardio protection now our there are many pioneers in the concept of ventricular load but more recently there have been a lot of pioneers in the field of unloading and so Dan Burke off David cast my mentors Kenji soon Ogawa all been focusing on this concept of unloading through heart rate modulation as well as through pressure and volume modulation and in 1975 the earliest paper that was put out essentially showed his concept of the pressure volume area being directly coupled to myocardial oxygen consumption and when we look more carefully at oxygen consumption it's crossbridge cycling excitation contraction cou