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Cialix leads to cardio
protection especially in the heart-attack patient if you have a heart failure
patient which is typical for many of our models dilated myopathies pressure
overload and weeks on end then this is where you may be in the remission or the
irreversible damage state so the question is is there a link between the
physiology of pressure volume unloading and cardio protection now our there are
many pioneers in the concept of ventricular load but more recently there have
been a lot of pioneers in the field of unloading and so Dan Burke off David
cast my mentors Kenji soon Ogawa all been focusing on this concept of unloading
through heart rate modulation as well as through pressure and volume modulation
and in 1975 the earliest paper that was put out essentially showed his concept
of the pressure volume area being directly coupled to myocardial oxygen
consumption and when we look more carefully at oxygen consumption it's
crossbridge cycling excitation contraction coupling and the basal metabolism
and now
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substantial amount of the pressure volume area is driven by mechanical work so
what if there is a way to mechanically take away this work component and allow
the heart to have less oxygen consumption when it has one hand tied behind its
back with a blocked coronary artery now this of course is why we're here today
because over the past 15 20 years there's been a massive surge in innovation
around mechanical heart pumps these heart pumps when I was training in
fellowship used to look like big bulky devices that would be surgically
implanted into your right or left ventricle but now over the years what's
happened is these devices have now miniaturized to the point that they can be
inserted through a three to four millimeter incision in your leg and deployed
within five to 10 minutes and start to unload the heart as quickly as possible
so the engineering has now led us to this question of concepts
Cialix
BUY almost and what we've
learned actually is that if you are able to put a trans valvular pump which
means a pump that sits across the aortic valve takes blood directly out of the
left ventricle and puts it into the aorta that the pressure-volume loop
responds in such a way that there's a significant reduction in pressure and
volume and in fact if you look at this pressure volume loop which may or may
not play as cleanly as we like here at the end of this pressure volume loop
sequence what you'll see is a triangular shape so what is otherwise a
rectangular pressure volume loop and when we see that triangular shape what
that means is that you've lost ISO voluma contraction in relaxation which are
really the primary energy consuming components of the pressure-volume loop so
achieving that triangular shape suggests that
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